Novel Antimicrobials and AMR Diagnostics 2019


Antibiotic resistance spreading across Europe

Antimicrobial resistance (AMR) has increased by 32% since 2007 in Europe, according to a brand new report.

A new Lancet report based on data the EARS-Net provided in 2015 counts 33,000 deaths due to AMR, 39% thereof caused by infections with bacteria resistant to last-line antibiotics such as carbapenems and colistin. According to estimates of the European Centers for Disease Control and Prevention (ECDC) there were just 25,100 AMR-related deaths in 2007.

The study authors say that the burden of these infections is comparable to that of influenza, tuberculosis and HIV/AIDS combined but that the contribution of various antibiotic-resistant bacteria to the overall burden varies greatly between countries. According to the study, 75% of the burden of disease is due to healthcare-associated infections (HAIs).

However, the problem doesn't seem to be limited to hospital-acquired infections. Researchers at the Julius Kühn Institute, Germany, reported in mBIO that fruit and vegetable is a reservoir for transferable antibiotic resistance genes that often escape traditional molecular detection methods. These antibiotic resistance genes might escape cultivation-independent detection methods such as PCR but could still be transferred to human pathogens or commensals.

The team mixed 24 samples of salad, arugula, and cilantro purchased from supermarkets in Germany to analyse the transferable antibiotic resistance genes in bacteria by cultivation and DNA-based methods. Although initially low in abundance, TET-resistant E. coli were isolated from all purchased produce samples after nonselective enrichment. TET-resistant E. coli isolates were mostly isolated from cilantro followed by mixed ready-to-eat salad and arugula. They further demonstrated that multi-drug resistance plasmids were transferable to sensitive E. coli recipients, a process that could occur in the human gut.